Male with myelofibrosis and ulceronecrotic lesions

SUMMARY Granulocytic sarcoma also called myeloid sarcoma is an extramedullary tumour of immature granulocytic cells. It is a rare entity, and mostly accompanied by acute myeloid leukaemia. It is observed during the course of myeloproliferative disorders especially in chronic myeloid leukaemia and myelodysplastic syndromes. Here, we report a case of a 60-year-old male with past history of myelofibrosis admitted to the emergency room due ulceronecrotic lesions, fever and dysphagia. We emphasize the importance of recognizing this entity and its severity.

RESUMO O sarcoma granulocítico, também chamado de sarcoma mieloide, é um tumor extramedular de células granulocíticas ¡maturas. É uma entidade rara, e principalmente acompanhada de leucemia mieloide aguda. É observado durante o transtorno mieloproliferativo, especialmente na leucemia mieloide crónica e síndromes mielodisplásicas. Aqui, relatamos um caso de um homem de 60 anos com antecedente de mielofibrose admitida na sala de emergência devido a lesões ulceronecróticas, febre e disfagia. Enfatizamos a importância de reconhecer essa entidade e sua gravidade.

A t(8;9)(p22;p24)/PCM1-JAK2 Translocation in a Patient With Myeloproliferative Neoplasm and Myeloid Sarcoma: First Report in Korea

No abstract available.

Granulocytic sarcoma.

We present two cases where GS was sole presentations, months before the diagnosis of AML.

Granulocytic sarcoma.

Granulocytic sarcoma (GS) is an extramedullary tumor mostly associated with acute or chronic myelogenous leukemia (AML). GS can virtually involve any structure in body. Rarely the tumor may be seen before the diagnosis of underlying hematological malignancies. We present two cases where GS was sole presentations, months before the diagnosis of AML.

Granulocytic sarcoma causing cord compression in a pregnant woman with acute myeloid leukemia and t[8;21]

Chloroma or granulocytic sarcomas [GSs] are solid tumors originating from myeloid precursors. Most frequently they occur in acute myeloid leukemia [AML], myeloproliferative disorder, and myelodysplasia. It may involve any organ system, but mostly it affects the bone and soft tissue of the head and neck. Granulocytic sarcoma resulting in spinal cord compression is rare. The association between t[8;21], and GS has been reported. In spite of the fact that t[8;21] is considered to be associated with good prognosis, patients with GS and spinal cord compression had less favorable prognosis than other AML patients with t[8;21]. Radiotherapy, chemotherapy, and surgical decompression are the accepted methods of therapy. However, aggressive therapy such as transplantation may be warranted early in the therapeutic strategy. Pregnancy associated with AML is rare. In our research, only one case of pregnancy with GS and AML has been previously reported. We are reporting a pregnant female diagnosed with AML/M2 with t[8;21] at the first trimester, who relapsed with GS, and cord compression at full term. She had a normal baby, and achieved second remission post-chemotherapy. Unfortunately, shortly after this she had a relapse, and died

Isolated Biliary Granulocytic Sarcoma Followed by Acute Myelogeneous Leukemia with Multilineage Dysplasia: A Case Report and Literature Review

Granulocytic sarcoma is a rare extramedullary tumor composed of myeloid progenitor cells. Primary involvement of the biliary tract without evidence of leukemia is exceedingly rare. Here, we report an isolated biliary granulocytic sarcoma in a 30-yr-old man who presented with jaundice, fever, and chill without any evidence of leukemia. However, five months after the diagnosis, he developed acute myelogenous leukemia with multilineage dysplasia and chromosomal abnormality. A rare possibility of biliary granulocytic sarcoma should be considered as a differential diagnosis in patients with obstructive jaundice. A histologic evaluation by aggressive diagnostic intervention is important and may improve prognosis.

Spinal granulocytic sarcoma (chloroma) presenting as acute cord compression in a nonleukemic patient.

The case of a previously healthy 24-year-old man diagnosed with extradural thoracic granulocytic sarcoma with no evidence of bone marrow or other hematological involvement is described. The tumor was removed totally by microsurgery. The histopathological examination was consistent with granulocytic sarcoma. Granulocytic sarcomas are most commonly found in the context of an acute myelogenous leukemia or in chronic myelogenous leukemia. They rarely have been reported in otherwise healthy patients without any evidence of systemic disease. A review of the literature revealed only 14 more nonleukaemic cases with granulocytic sarcoma causing thoracic spinal cord compression.